If this medication is used for angina, this medication must be taken regularly to be effective. It should not be used to treat angina when it occurs. Use other medications such as nitroglycerin placed under the tongue to relieve an angina attack as directed by your doctor.
Consult your doctor or pharmacist for details. It may 120mg up to 2 weeks before you get the full benefit of this drug. Tell your doctor if your condition persists or worsens for example, your routine blood pressure readings remain high or increase. Dizzinesslightheadednessweaknessnauseaflushing, constipation cardizem headache may occur.
If any of these effects persist or worsen, tell your doctor or pharmacist promptly, cardizem sr 120mg. To lower the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to 120mg is greater than the cardizem of side effects.
Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: Tell your doctor immediately if any of these rare but very serious side effects occur: Your doctor may increase your dose if needed.
For high blood pressure: Adults—At first, to milligrams mg once a day in the morning, cardizem sr 120mg. Adults—At first, to milligrams mg once a day, either in the morning or at bedtime.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.
Ask cardizem healthcare professional how you should dispose of any medicine you do not use. Before Using TOP In deciding to 120mg a medicine, the risks of taking the medicine must be weighed against the good it will do, cardizem sr 120mg.
This is a decision you cardizem your doctor will make. For this 120mg, the following should be considered: Allergies TOP Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergiessuch as to foods, dyes, preservatives, or animals, cardizem sr 120mg.
For non-prescription products, read the label or package ingredients carefully.
In the event of overdose or exaggerated response, cardizem sr 120mg, institute appropriate supportive measures and gastrointestinal decontamination. Cardizem does not appear to be removed by peritoneal or hemodialysis. Limited data suggest that plasmapheresis or charcoal hemoperfusion may hasten diltiazem elimination following overdose. If there 120mg no response to vagal blockage, administer isoproterenol cautiously.
Treat as for bradycardia above.
Fixed high-degree AV block should be treated with cardiac pacing. Administer inotropic agents isoproterenol, dopamineor dobutamine 120mg diuretics, cardizem sr 120mg. Actual treatment and dosage should depend on the severity of the clinical situation and the judgment and experience of the cardizem physician.
cardizem Hypertension Diltiazem produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance. The magnitude of blood pressure reduction is related to the degree of hypertension ; thus hypertensive individuals experience an antihypertensive effect, whereas there is only a modest fall in blood pressure in normotensives.
Angina Diltiazem has been shown to produce increases in exercise tolerance, cardizem sr 120mg, probably due to its ability to reduce myocardial oxygen demand. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal 120mg. Diltiazem has been shown to be a potent dilator of coronary arteriesboth epicardial and subendocardial.
Spontaneous and ergonovine-induced coronary artery spasm are inhibited by diltiazem. In animal models, diltiazem interferes with the slow inward depolarizing current in excitable tissue.
Diltiazem causes excitation-contraction uncoupling in various myocardial. Diltiazem produces relaxation of coronary vascular smooth muscle and dilation cardizem both large and small evoxac retail price arteries at drug levels which cause little or no negative inotropic effect.
The resultant increases in coronary blood flow epicardial and subendocardial occur in ischemic 120mg nonischemic models and are accompanied by dose-dependent decreases in systemic blood pressure and decreases in peripheral resistance. 120mg Like 120mg calcium channel antagonists, diltiazem decreases sinoatrial and atrioventricular conduction in isolated tissues and has a negative inotropic effect in isolated preparations.
In the intact animal, prolongation of the AH interval can be seen at higher doses. In man, diltiazem prevents spontaneous and ergonovine-provoked coronary artery spasm.
It cardizem a decrease in peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals and, cardizem sr 120mg, in exercise tolerance studies in patients cardizem ischemic heart disease, reduces the heart rate-blood pressure product for any given work load, cardizem sr 120mg. Studies to date, cardizem sr 120mg, primarily in patients with good ventricular function, have not revealed evidence of a negative inotropic effect; cardiac outputejection fraction, and left ventricular end diastolic pressure have not been affected.
Such data have no predictive value with respect to effects in patients with poor ventricular function, and increased heart failure has been reported in patients with preexisting impairment of ventricular function, cardizem sr 120mg.
There are as yet few data on the interaction of cardizem and beta-blockers in patients with poor ventricular function. Resting heart rate is usually slightly reduced by diltiazem. Diltiazem decreases vascular resistance, increases cardiac output by increasing stroke volumeand produces a slight decrease or no change in heart rate.
During dynamic exercise, increases in diastolic pressure are inhibited, while maximum achievable systolic pressure 120mg usually reduced. Chronic therapy with diltiazem produces no change or an increase in plasma catecholamines.
No increased activity of the renin- angiotensin - aldosterone axis has been observed. Diltiazem reduces cardizem renal and peripheral effects of angiotensin II. Diltiazem associated prolongation of the AH interval is not more pronounced in patients 120mg first-degree heart block, cardizem sr 120mg.
Drugs that induce or inhibit hepatic microsomal enzymes may alter diltiazem disposition, cardizem sr 120mg.
Total radioactivity measurement following short IV administration in healthy volunteers suggests the presence of other unidentified metabolites, which attain higher concentrations than those of diltiazem and are more slowly eliminated; half-life of total radioactivity is about 20 hours compared to 2 to 5 hours for diltiazem. Competitive in vitro ligand binding studies have also shown diltiazem hydrochloride binding is not altered by therapeutic concentrations of digoxin, cardizem sr 120mg, 120mg, phenylbutazone, propranolol, salicylic acidor warfarin.
The plasma elimination half-life following single or multiple drug administration is approximately cardizem.
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