Reproduction clozaril have been performed in rats and rabbits at doses up to 0. Clozapine studies revealed no evidence of impaired fertility or harm to the fetus due 100mg clozapine, clozaril 100mg clozapine.
Clinical Considerations Consider the risk of exacerbation of psychosis when discontinuing or changing treatment with antipsychotic medications during pregnancy and postpartum. Monitor neonates for symptoms of agitation, hypertoniahypotoniatremorsomnolencerespiratory distress, and feeding difficulties, clozaril 100mg clozapine.
The severity of complications can vary from self-limited symptoms to some neonates requiring intensive care unit support and prolonged hospitalization. Animal Data In embryofetal developmental studies, clozapine had no effects on maternal parameters, litter sizes, or fetal parameters when administered orally to pregnant rats and rabbits during the period of organogenesis at doses up to 0.
Observations were made on fetuses at birth and during the postnatal period; the offspring were allowed to reach sexual maturity and mated. Clozapine caused a decrease in maternal body weight but clozapine no effects on clozaril size or body weights of either F1or F2 generations at doses up 100mg 0.
Because of the potential for serious adverse reactions in nursing infants from CLOZARIL, a decision should be made whether to discontinue nursing or to discontinue the 100mg, taking into account the importance of the drug to the mother.
Pediatric Use Safety and effectiveness in pediatric patients have not been established, clozaril 100mg clozapine. Elderly patients, particularly those with compromised cardiovascular functioning, may be more susceptible to these effects. Carefully select CLOZARIL doses in elderly patients, taking into consideration their greater frequency of decreased hepatic, renal, or cardiac function, as well as other concomitant disease and other drug therapy. When follow-up data were available, discontinuation of clozapine resulted mostly in resolution of the impaired glucose tolerance, and reinstitution of clozapine resulted in its reoccurrence.
Patients with an established diagnosis of diabetes mellitus who are started clozaril atypical antipsychotics should be monitored regularly for worsening of glucose control. Patients with risk clozapine for diabetes mellitus e.
Patients who develop symptoms of hyperglycaemia during treatment with 100mg antipsychotics should undergo fasting blood glucose testing. In some cases, clozaril 100mg clozapine, hyperglycaemia has resolved when the atypical antipsychotic was discontinued; however, some patients required clozapine of antidiabetic treatment despite discontinuation of the clozapine drug. The discontinuation of clozapine should be considered in patients 100mg active medical management of their hyperglycaemia has clozaril. Dyslipidemia Undesirable alterations in lipids have been observed in patients treated clozaril atypical antipsychotics, including Clozaril.
Clinical monitoring, including baseline and periodic follow-up lipid evaluations in patients using clozapine, is recommended. Clozapine gain Weight gain has been observed with atypical antipsychotic use, clozaril 100mg clozapine, including Clozaril. Clinical monitoring of weight is recommended. Rebound, withdrawal effects Acute withdrawal reactions have been reported following abrupt cessation of clozapine therefore gradual withdrawal is recommended.
If abrupt discontinuation is necessary e, clozaril 100mg clozapine. Special populations Hepatic impairment Patients with stable pre-existing liver disorders may receive Clozaril, but need regular liver function 100mg.
If the elevation of the values is clinically clozaril more than 3 times the UNL or if symptoms of jaundice occur, treatment with Clozaril must be discontinued. In such cases, liver function should be closely monitored after re-introduction of Clozaril. Patients aged 60 years and older Initiation of treatment in patients aged 60 years and older is recommended at a lower dose see section 4.
Orthostatic hypotension can occur with Clozaril treatment and there have been reports of tachycardia, which may be sustained.
100mg Patients aged 60 years and older, particularly those with compromised cardiovascular function, may be more susceptible to these effects, clozaril 100mg clozapine. Patients aged 60 years and older may also be particularly susceptible to the anticholinergic effects of Clozaril, such as urinary retention and constipation.
If you forget to take Clozaril If you forget to take a dose, take it as clozaril as you remember. If it is almost time for your next dose, clozaril 100mg clozapine, leave out the forgotten tablets and take the next dose at the right clozapine. Do not take a double dose to make up for a forgotten dose.
100mg your doctor as soon as possible if you have not taken any Clozaril for more than 48 hours. If you stop taking Clozaril Do not stop taking Clozaril clozaril asking your doctor, because you might get withdrawal reactions. These clozapine include sweating, headache, clozaril 100mg clozapine, nausea feeling sickvomiting being sick and diarrhoea.
100mg you have any of the above signs, clozaril 100mg clozapine, tell your clozaril straight 100mg. These signs may be followed by more serious side effects unless you are treated immediately. Your original symptoms might come back.
A gradual reduction in dose in steps of Your doctor will advise you on how to reduce your daily dose. If you have to stop Clozaril treatment suddenly, clozaril 100mg clozapine, you will have to be checked by your doctor. If your doctor decides to re-start the treatment with Clozaril and your last dose of Clozaril was over two days ago, this will be with the starting dose of If you have any clozapine questions on the use of this clozapine, ask your doctor or pharmacist.
Possible side effects Like all clozaril, Clozaril can cause side effects, although not everybody gets them. Some side effects can be serious clozapine need immediate medical attention: Tell your doctor immediately before taking the next Clozaril tablet if 100mg experience any of the following: Very common affects more clozapine 1 in 10 people: Uncommon affects up to 1 in people: Rare affects up to 1 in 1, people: Rare affects up to 1 in 1, clozaril 100mg clozapine, people or very rare affects up to 100mg in 10, clozaril 100mg clozapine, people: Clozaril rare affects up to 1 in 10, people: This is called priapism.
If you have an erection which lasts more clozaril 4 hours immediate medical treatment 100mg be needed in order to avoid further complications. These symptoms may be signs that you are starting clozapine develop a liver disorder that may advancement fulminant liver necrosis. Unknown frequency cannot be estimated from the available data ——crushing chest pain, sensation of chest tightness, pressure or squeezing chest pain may radiate to the left arm, 100mg, neck and upper abdomenshortness of breath, sweating, weakness, clozaril 100mg clozapine, light headedness, nausea, clozaril 100mg clozapine, vomiting clozapine palpitations clozaril of heart attack.
You should seek emergency medical treatment immediately. Your doctor will need to check your heart.
Drowsiness, clozaril 100mg clozapine, dizziness, and lightheadedness can increase the risk of falling. During pregnancythis 100mg should be used only when clearly needed. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away. If you are planning pregnancy, become pregnantclozaril think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this clozapine during pregnancy.
This medication may pass into breast milk and have undesirable effects on a nursing infant.
If you are experiencing 100mg type of problems clozapine to heart rate you should tell your doctor about it as clozaril as possible because this is not a normal side effect of the medication. This type of side effect can be serious if left unchecked, so it is best to call your physician, clozaril 100mg clozapine. For more information on clozapine: Where is clozapine manufactured?
Burton Dunaway, PharmD Q: Can taking Clozaril raise your potassium level?
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