Renagel generic price - Renagel (Sevelamer Hcl): Side Effects, Interactions, Warning, Dosage & Uses
There are no reports of overdosage with Renagel in patients. Since Renagel is not absorbed, the risk of systemic toxicity is low. Renagel is contraindicated in patients with known hypersensitivity to sevelamer hydrochloride or to any of the excipients. High serum phosphorus can precipitate serum calcium resulting in ectopic calcification, renagel generic price.
Hyperphosphatemia plays a role in the development of secondary hyperparathyroidism in renal insufficiency.
Treatment of hyperphosphatemia includes reduction in dietary intake of phosphate, inhibition of intestinal phosphate renagel with phosphate binders, and removal of phosphate with dialysis, renagel generic price. Renagel taken with meals has been shown to decrease serum phosphorus concentrations in patients with CKD who are on dialysis. Mechanism Of Action Renagel contains sevelamer hydrochloride, a non-absorbed binding crosslinked polymer. It contains multiple amines separated by one carbon from the polymer backbone.
These amines exist in a protonated form in the intestine generic interact with phosphate molecules through ionic and price bonding, renagel generic price.
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By binding phosphate in the dietary tract and decreasing absorption, sevelamer hydrochloride prices the phosphate concentration in the serum.
Pharmacodynamics In addition to effects on serum phosphate levels, sevelamer hydrochloride has been shown to bind bile acids in vitro and in vivo in experimental animal models.
Bile acid binding by ion exchange resins is a well-established method of lowering blood cholesterol. Because sevelamer binds bile acids, it may interfere with generic fat absorption and thus may reduce absorption of fat-soluble vitamins such as A, Renagel and K.
This effect is observed after 2 weeks, renagel generic price.
TriglyceridesHDL cholesterol and albumin did not change. Pharmacokinetics A mass balance study using 14C-sevelamer hydrochloride in 16 healthy male and female volunteers showed that sevelamer hydrochloride is not systemically absorbed. No absorption studies have been performed in patients with renal disease. Drug Interactions In vivo Renagel price has been studied in human drug-drug interaction studies 9.
Sevelamer hydrochloride, which contains the same active moiety as sevelamer carbonate, has been studied in generic drug-drug interaction studies 2, renagel generic price.
Co-administered single dose of 2. Sevelamer carbonate or sevelamer hydrochloride did not alter the pharmacokinetics of a single dose of enalapril, digoxin, price, metoprolol and warfarin generic co-administered, renagel generic price.
During postmarketing experience, cases of renagel thyroid stimulating hormone TSH levels have been reported in patients co-administered sevelamer hydrochloride and levothyroxine. Reduction in concentrations of cyclosporine and tacrolimus generic to dose increases has also been reported in transplant patients when co-administered with sevelamer hydrochloride without any clinical consequences for example, graft rejection.
Renagel possibility of an interaction cannot be excluded with these drugs. Clinical Studies The ability of Renagel to lower price phosphorus in CKD patients on dialysis was demonstrated in six clinical trials: Three of the active-controlled studies are described here.
One is a crossover study with two 8-week periods comparing Renagel to an active-control. This may not be a complete list of all interactions that may occur, renagel generic price.
Ask your health care provider if Renagel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Renagel may reduce generic vitamins in your body. Check with your doctor about whether or not renagel should take a vitamin supplement while you take Renagel. Follow the diet program given to you by your health care provider. Lab tests, including calcium, renagel generic price, bicarbonate, and chloride blood levels, may be performed while you use Renagel. These tests may be used to monitor your price or check for side effects.
Be sure to keep all price and lab appointments. Renagel should be generic with extreme caution in children; safety and effectiveness renagel children have not been confirmed. If you become pregnant, contact your doctor, renagel generic price.
Sevelamer - Price List of 8 Brands
You will need to discuss the benefits and risks of using Renagel while you are pregnant. It is not known if Renagel is found in breast milk. If you are or will be breast-feeding while you use Renagel, check with your doctor. Discuss any possible risks to your baby. Side effects All medicines may cause side effects, but many people have no, or minor, side effects.
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